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Clinical Studies
There is a good deal of data on clinical outcomes and a few randomised trials but none really of the quality to influence NICE and hence make treatment available on the NHS or with insurers support privately. My priority is to establish a double blind RCT for early knee OA. Most of the studies thus far are observational, but admittedly with large numbers.
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One-year-survey with multicenter data of more than 4,500 patients with degenerative rheumatic diseases treated with therapeutic nuclear magnetic resonance.4
Background: Nuclear magnetic resonance (NMR) has been shown to stimulate repair processes and cartilage and to influence pain signalling. It represents an alternative therapy for patients suffering from osteoarthritis (OA).
To prove the clinical success of this new therapeutical method, validated measuring parameters are important that are convincing for pain and function in a one-year-follow-up.
Method: During the course of its application over the last
10 years, over 4,500 protocols of a one-year-follow-up have been collected to record the outcome of NMR therapy. This report reflects the outcome of NMR therapy on patients with the following degenerative rheumatic diseases: OA of the knee (n = 2.770), OA of the hip (n = 673), OA of the ankle joint (n = 420) and chronic low back pain (n = 655). Data were collected at baseline, 6–8 weeks and 6 and 12 months following NMR treatment.
Results: Pain was reduced significantly 6 weeks after NMR treatment in the cases of all four examined indications and stayed measurably reduced up to 6 and 12 months. The improvements in all three forms of pain (pain on load, pain on motion, pain at rest) following NMR treatment were around 21–50% on average.
Conclusion: Following therapy with NMR, patients with OA of all four types experienced a distinct improvement in their ability in functional parameters. Overall, the 10 years of a one-year-survey with multicenter data gathered on the effect of NMR therapy
on patients verifiably proved its efficacy amongst patients with degenerative rheumatic diseases.
The effect of MBST®NuclearMagneticResonanceTherapy with a complex 3-dimensional electromagnetic nuclear resonance field on patients with Low Back Pain.5
The study included 62 patients (36 men, 26 women) aged 18 to 71 (mean age: 48.1 years) with low back pain. All patients were entered into a standardised 3 week inpatient rehabilitation program. All patients were given MBST but half of the treatment cards did not produce the MRI field ensuring double blind randomisation for MBST treatment.
At 3 weeks both groups of patients had improved across all parameters but by 3 months the control group scores had regressed to baseline whereas the MBST group continued to improve.
REFERENCES
1 The therapeutic nuclear magnetic resonance changes the balance in intracellular calcium and reduces the interleukin-1 induced increase of NF-ĸB activity in chondrocytes
B. Steinecker-Frohnwieser, W. Kullich, A. Mann, H.-G. Kress, L. Weigl, Clinical and Experimental Rheumatology, PMID 29185963
2. NMR In Vitro Effects on Proliferation, Apoptosis, and Viability of Human Chondrocytes and Osteoblasts A. Temiz- Artmann, P. Linder, P. Kayser, I. Digel, G.M. Artmann, P. Luecker, Methods and Findings Exp. Clin. Pharmacol., 27(5), 391–394
3. Decrease in extracellular collagen crosslinking after NMR magnetic field application in skinfibroblasts G. M. Artmann, A. Temiz Artmann, I. Digel, E. Kurulgan, Pt. Linder,
P. Kayser, D. Porst, G. J. Braem, K. Zerlin, Journal of the International Federation for Medical and Biological Engineering, 45, 91–97
4. W. Kullicha, J. Overbeckb and H.U. Spiegelc Journal of Back and Musculoskeletal Rehabilitation 26 (2013) 93–104
5. Journal of Back and Musculoskeletal Rehabilitation, 19, 2006, 79–87 Kullich W, Schwann H, Walcher J.
Jonathan Webb
MB ChB FRCS (Orth)
Consultant Knee Surgeon
T: +44 (0) 203 195 2443
E: jonathan.webb@fortiusclinic.com W: www.fortiusclinic.com
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